London’s famous puzzle solving professor, Hershel Layton and his apprentice Luke Triton take on the most scariest and spookiest mystery yet. In London, things gradually become more deserted and empty, as the Professor and Luke notice as they go along their normal day. Eventually, they notice something ominous…and hairy. Intense and angry werewolves have started to plague London! Meanwhile, Pendulum City’s butt kicking hero, Emerald Cat, and his sidekick/girlfriend Amethyst Cat, have come to realize the exact same problem, as the city gradually becomes more deserted, and later on, plagued with the same werewolves like London! This mystery requires the team-up of Professor Layton and Emerald Cat, as they endure the spooky and mysterious adventure to solve the mystery of the werewolves! What seems to be caused by a mysterious curse, from the Moon Pearl.