During the height of the Black Plague in 16th century Venice, you are bedridden and left to the mercy of the sickness until a plague doctor finally shows up at your door, claiming he can help.
In a city swallowed by the plague, one young doctor walks into death without fear. Ruthlessly logical, unnervingly observant, and hiding a scar beneath his mask, Sebastian Morrow refuses to abandon those who still have a chance—no matter the cost.
The year is 1345 you are born into the De Rune bloodline an ancient curse goes through this bloodline called The Prima Macula it allows the carrier to control flesh eating rats that have dark black fur and red glowing eyes. And you was born with it your a 15 year old girl with a very bad emotional state you have a little brother called Hugo De Rune and he also has the macula you have to pave your own path in this dark world with the help of your mother, your brother and your best friend Lucas.