The story finds Selene targeted by both the Lycan clan and the Vampire faction that betrayed her. The Lycans have unified under a ruthless new leader, Marius, who seeks to hunt down Selene and her daughter to harvest their pure blood for unmatched power. To survive and safeguard the future of her kind, Selene travels north to a hidden coven to unlock new abilities. She must make the ultimate sacrifice to bring a definitive end to the centuries-old eternal war.