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Peter Parker has retired as Spider-Man to build a peaceful life with his pregnant wife Gwen and their children, leaving New York without its longtime protector. Then fourteen-year-old Ronnie Wade is bitten by an altered spider at Alchemax and develops extraordinary abilities of his own. With Peter reluctantly becoming his mentor, Ronnie must learn how to balance school, family, dangerous new powers, and the responsibility of becoming Earth-42’s next Spider-Man—without losing himself beneath someone else’s mask.