After surviving the Raccoon City outbreak as a child infected with a stable virus, Emma is taken under the unofficial care of Leon S. Kennedy and later becomes a classified government agent alongside Sherry Birkin. At 25, Emma works in bioterrorism containment missions, using her enhanced resilience and partial viral resistance. When a global outbreak linked to Neo-Umbrella begins, she is assigned with Sherry to capture Jake Muller, a mercenary tied to the origins of the C-Virus. The mission quickly turns into a worldwide pursuit, forcing Emma to confront Jake, question the government she serves, and face the truth about her own biological condition.