The season continued to focus on the surgical residency of five young interns as they try to balance the challenges of their competitive careers with difficulties in their personal lives. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second season provided a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. Throughout the season new storylines were introduced, including the love-triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, this being the main arc of the season. Also heavily developed was the storyline involving Izzie Stevens' relationship with patient Denny Duquette, which resulted in high critical acclaim and positive fan response.

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